Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Genetics of Speciation02:16

Genetics of Speciation

21.9K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.9K
What is Population Genetics?01:25

What is Population Genetics?

65.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.4K
Overview
80.4K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a core outcome set for clinical trials of extended reality for pain.

Pain reports·2026
Same author

Outcomes of Lung Transplantation for Pulmonary Sarcoidosis Across Multiple Eras: A 25-Year Experience from a US Center.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2026
Same author

Development of novel Aotus nancymaae non-human primate model for the evaluation of Plasmodium vivax blood stage vaccines and immunoprophylactics.

Malaria journal·2026
Same author

Objective clinical scoring system and diagnostic variability in idiopathic pulmonary fibrosis.

BMC pulmonary medicine·2026
Same author

Large-scale, real-world collection of refractive outcomes after cataract surgery through patient-mediated mobile photography.

Eye (London, England)·2026
Same author

Evaluation of Routine Clinical Deployment of an Autonomous Artificial Intelligence Assistant for Cataract Follow-Up in the National Health Service.

Clinical ophthalmology (Auckland, N.Z.)·2026

Related Experiment Video

Updated: Feb 12, 2026

Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

13.3K

Recent Genetics and Epigenetics Approaches to PTSD.

Nikolaos P Daskalakis1, Chuda M Rijal1, Christopher King1

  • 1Division of Depression & Anxiety Disorders, McLean Hospital, Department of Psychiatry, Harvard Medical School, Oaks Building 328, Mailstop 212, 115 Mill Street, Belmont, MA, 02478-1064, USA.

Current Psychiatry Reports
|April 7, 2018
PubMed
Summary

Genetic and epigenetic factors significantly influence the risk of developing posttraumatic stress disorder (PTSD) after trauma. Environmental factors interact with genetic predispositions to alter gene expression, impacting PTSD development.

Keywords:
DNA methylationEpigeneticsGWASGeneticsPTSD

More Related Videos

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.8K
DNA Extraction from Paraffin Embedded Material for Genetic and Epigenetic Analyses
13:32

DNA Extraction from Paraffin Embedded Material for Genetic and Epigenetic Analyses

Published on: March 26, 2011

57.4K

Related Experiment Videos

Last Updated: Feb 12, 2026

Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

13.3K
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.8K
DNA Extraction from Paraffin Embedded Material for Genetic and Epigenetic Analyses
13:32

DNA Extraction from Paraffin Embedded Material for Genetic and Epigenetic Analyses

Published on: March 26, 2011

57.4K

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Posttraumatic stress disorder (PTSD) affects approximately 10% of individuals after life-threatening trauma.
  • PTSD is characterized by intrusive memories, nightmares, avoidance, hyperarousal, cognitive impairment, and negative emotions.

Purpose of the Study:

  • To review recent genetic and epigenetic approaches to understanding differential risk for PTSD.
  • To explore how genetic and epigenetic factors contribute to PTSD vulnerability.

Main Methods:

  • Review of large-scale genome-wide association studies (GWAS).
  • Analysis of epigenome-wide association studies (EWAS).
  • Discussion of future phenome-wide and targeted genetic studies.

Main Results:

  • Genetic and epigenetic factors account for a significant portion of differential risk for PTSD.
  • Environmental factors, including trauma history, induce epigenetic changes that alter gene regulation.
  • Inherited and acquired genetic/epigenetic risks are crucial in PTSD development.

Conclusions:

  • Genetic and epigenetic mechanisms are central to understanding individual differences in PTSD risk.
  • Future research should integrate genetic, epigenetic, and environmental data for a comprehensive understanding of PTSD.
  • Targeted studies are needed to elucidate the precise mechanisms of genetic and epigenetic alterations in PTSD.