Related Experiment Video

Updated: Feb 12, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

14.0K

Treatment of Metastatic, Castration-resistant, Docetaxel-resistant Prostate Cancer: A Systematic Review of Literature

Davide Tassinari1, Chiara Cherubini2, Britt Roudnas1

  • 1Department of Oncology, City Hospital, Rimini, Italy.

Reviews on Recent Clinical Trials
|April 7, 2018
PubMed
Abstract

Insights

No significant difference in overall survival was found between abiraterone acetate, enzalutamide, cabazitaxel, and Radium-223 for metastatic prostate cancer. Enzalutamide showed a benefit in time to PSA progression.

Area of Science:

  • Oncology
  • Medical Research
  • Clinical Trials

Background:

  • Investigating advanced treatments for metastatic prostate cancer.
  • Focusing on castration-resistant and docetaxel-resistant disease stages.

Purpose of the Study:

  • To compare the efficacy of four key treatments: abiraterone acetate, enzalutamide, cabazitaxel, and Radium-223.
  • To evaluate overall survival and time to prostate-specific antigen (PSA) progression.

Main Methods:

  • Conducted a network meta-analysis of indirect comparisons.
  • Primary endpoint: Overall Survival (OS) in the entire patient population.
  • Secondary endpoints included subgroup analyses and time to PSA progression.

Main Results:

  • No statistically significant difference in OS was observed among the four treatments in the overall population or subgroups.
  • Enzalutamide demonstrated a significant advantage over abiraterone acetate, cabazitaxel, and Radium-223 for time to PSA progression.

Conclusions:

  • The four therapeutic options show comparable efficacy in terms of overall survival for advanced prostate cancer.
  • Clinical decisions should prioritize treatment safety, patient adherence, and cost-effectiveness.
Keywords:
Abiraterone Acetatecabazitaxelcastration-resistant metastatic diseaseenzalutamideprostate cancerradium-223.

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.9K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.2K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.1K
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.9K
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K