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Updated: Feb 12, 2026
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Use of pHluorin to Assess the Dynamics of Axon Guidance Receptors in Cell Culture and in the Chick Embryo
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SNARE complex in axonal guidance and neuroregeneration
Fausto Ulloa1, Tiziana Cotrufo1, Delia Ricolo2
1Department of Cell Biology, Physiology and Immunology, School of Biology, and Institute of Neurosciences, University of Barcelona, Barcelona; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Neural Regeneration Research
|April 7, 2018
Summary
Soluble N-ethylamaleimide Sensitive Factor (NSF) Attachment Protein Receptor (SNARE) proteins are crucial for axonal growth, guidance, and neuroregeneration. This review explores their role in neuronal development and repair.
Area of Science:
- Neuroscience
- Cell Biology
Background:
- Axonal growth and guidance are essential for forming neuronal systems and synaptic circuitry.
- Neuroregeneration repairs damaged neural networks by re-establishing synaptic connections.
- Both development and regeneration depend on axonal growth, guidance cues, and target synapsis.
Purpose of the Study:
- To review the literature on Soluble N-ethylamaleimide Sensitive Factor (NSF) Attachment Protein Receptor (SNARE) proteins.
- To explore the involvement of SNARE proteins in axonal growth and guidance during embryonic development.
- To examine the role of SNARE proteins in neuroregeneration after injury.
Main Methods:
- Literature review of recent studies.
- Analysis of cellular and molecular processes.
- Focus on vesicle and membrane trafficking events.
Main Results:
- SNARE proteins are major players in growth cone development and movement.
- SNARE proteins are involved in axonal growth and guidance.
- SNARE proteins are critical for neuroregenerative responses.
Conclusions:
- SNARE proteins are vital for both embryonic axonal development and adult neuroregeneration.
- Understanding SNARE protein function is key to advancing neural repair strategies.
- Further research into SNAREs can elucidate mechanisms of neuronal system formation and repair.
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