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Updated: Feb 12, 2026

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
Published on: July 31, 2017
Neuroprotective effect of ischemic postconditioning on sciatic nerve transection
Xiao-Bin Zhou1, Na Liu2, Dong Wang3
1Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing; Department of Traumatic Orthopedics, the Third Hospital of Shijiazhuang, Shijiazhuang, Hebei Province, China.
Abstract:
Ischemic preconditioning or postconditioning has been shown to have neuroprotective effect on cerebral ischemia, but it has not been studied in peripheral nerve injury. In this study, a rat model of sciatic nerve transection was established, and subjected to three cycles of ischemia for 10 minutes + reperfusion for 10 minutes, once a day. After ischemic postconditioning, serum insulin-like growth factor 1 expression increased; sciatic nerve Schwann cell myelination increased; sensory function and motor function were restored. These findings indicate that ischemic postconditioning can effectively protect injured sciatic nerve. The protective effect is possibly associated with upregulation of insulin-like growth factor 1.
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