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Are diuretics effective for Ménière`s disease?
Andrés Rosenbaum1, Matías Winter2
1Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Medwave
|April 7, 2018
Summary
The effectiveness of diuretics for Ménière`s disease is uncertain. Current evidence is very low, meaning it is unclear if they improve vertigo or hearing loss in patients.
Area of Science:
- Otolaryngology
- Neurology
- Internal Medicine
Background:
- Ménière`s disease is an inner ear condition causing vertigo, hearing loss, and tinnitus.
- Diuretics are commonly prescribed for Ménière`s disease, but their efficacy is debated.
Purpose of the Study:
- To evaluate the effectiveness of diuretics in treating Ménière`s disease.
- To synthesize evidence from systematic reviews and primary studies.
Main Methods:
- Conducted a comprehensive search using Epistemonikos, a large database of systematic reviews.
- Extracted data from systematic reviews, reanalyzed primary studies, and performed a meta-analysis.
- Utilized the GRADE approach to assess the certainty of evidence.
Main Results:
- Identified three systematic reviews encompassing nineteen studies, including four randomized trials.
- The evidence regarding diuretic use in Ménière`s disease was found to be of very low certainty.
- No clear symptomatic improvement in vertigo or objective decrease in hearing loss was established.
Conclusions:
- The current evidence does not definitively support or refute the use of diuretics for Ménière`s disease.
- Further high-quality research is needed to clarify the role of diuretics in managing this condition.
- The very low certainty of evidence necessitates caution in clinical decision-making.