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Sarcomatoid pilomatrix carcinoma.

Angel Fernandez-Flores1,2,3, David S Cassarino4

  • 1Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.

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|April 7, 2018
PubMed
Summary

This study details a rare sarcomatoid pilomatrix carcinoma case in a 78-year-old man. Complete excision with Mohs surgery achieved no recurrence, offering insights into this aggressive skin cancer.

Keywords:
carcinosarcomapilomatricomapilomatrix carcinomapilomatrix carcinosarcomasarcomatoid pilomatrix carcinoma

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Pilomatrix carcinoma is a rare skin adnexal tumor with metastatic potential.
  • Sarcomatoid pilomatrix carcinoma is an exceptionally rare variant with both epithelial and sarcomatoid components.

Observation:

  • A 78-year-old male presented with a 6 mm hyperkeratotic, ulcerated plaque on his hand.
  • Histopathology revealed a dermal neoplasm with atypical basaloid and spindle-shaped cells.

Findings:

  • Immunohistochemistry confirmed both epithelial and sarcomatoid components expressed cytokeratins (CKs) AE1/AE3, CK 5/6, CAM 5.2, beta-catenin, and LEF-1.
  • The tumor was negative for CK7, CK20, S100, TTF1, CDX2, PSA, and CD34.

Implications:

  • This case expands the literature on sarcomatoid pilomatrix carcinoma, highlighting its presentation and immunohistochemical profile.
  • Successful complete excision using Mohs surgery suggests a viable treatment option for this rare malignancy.