Related Experiment Video

Updated: Feb 12, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K

Proteinuria and risk of stroke in patients with hypertension: The Kailuan cohort study

Anxin Wang1,2,3,4,5,6, Liye Dai1, Zhaoping Su1,2,3,4

  • 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|April 7, 2018
PubMed

Insights

Changes in proteinuria, especially persistent proteinuria, increase stroke risk in hypertensive patients. This highlights the importance of monitoring proteinuria for stroke prevention in this population.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiovascular Medicine

Background:

  • Proteinuria is a known risk factor for stroke.
  • The impact of dynamic changes in proteinuria on stroke risk in hypertensive individuals remains unclear.

Purpose of the Study:

  • To investigate the association between proteinuria changes over a 2-year period and the incidence of stroke in a hypertensive population.
  • To determine if different patterns of proteinuria (no, remittent, incident, persistent) correlate with varying stroke risks.

Main Methods:

  • Utilized data from 24,300 hypertensive participants in the Kailuan study, all stroke-free at baseline.
  • Classified proteinuria status based on dipstick screening at baseline and 2-year follow-up.
  • Employed Cox proportional-hazards models to analyze stroke risk, adjusting for covariates, over a median follow-up of 6.89 years.

Main Results:

  • A total of 1197 strokes were recorded during follow-up.
  • Compared to no proteinuria, incident proteinuria (HR 1.41) and persistent proteinuria (HR 1.49) were significantly associated with increased stroke risk after adjustments.
  • These associations were consistent for both ischemic stroke and intracerebral hemorrhage.

Conclusions:

  • Changes in proteinuria, particularly persistent proteinuria, are significant indicators of stroke risk in hypertensive patients.
  • Monitoring proteinuria dynamics is crucial for stroke risk assessment and prevention strategies in hypertension management.
  • No significant interaction was observed between proteinuria changes and diabetes mellitus regarding stroke risk in this cohort.

Keywords:
chronic kidney diseasehypertensionproteinuriastroke

More Related Videos

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients05:23

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients

Published on: March 11, 2021

2.9K
The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

1.6K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
610
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
957
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.0K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
490
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.8K