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Related Concept Videos

Mass Analyzers: Overview01:13

Mass Analyzers: Overview

1.8K
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
1.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.6K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.6K
Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.9K
Statistical Methods for Analyzing Epidemiological Data01:25

Statistical Methods for Analyzing Epidemiological Data

989
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
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Related Experiment Video

Updated: Feb 12, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

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SnapShot: TCGA-Analyzed Tumors.

Amy Blum1, Peggy Wang1, Jean C Zenklusen1

  • 1Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|April 7, 2018
PubMed
Summary

The Cancer Genome Atlas (TCGA) program has characterized numerous tumor types. This overview highlights key discoveries for each cancer type from TCGA marker papers.

Area of Science:

  • Oncology
  • Genomics
  • Cancer Research

Background:

  • The Cancer Genome Atlas (TCGA) program has generated comprehensive genomic data for various cancer types.
  • Understanding the molecular landscape of tumors is crucial for advancing cancer diagnosis and treatment.

Purpose of the Study:

  • To provide a consolidated list of tumor types analyzed by the TCGA program.
  • To summarize the most significant genomic discoveries for each characterized tumor type.

Main Methods:

  • Review of TCGA marker papers.
  • Identification of key findings related to tumor genomics.

Main Results:

  • A comprehensive catalog of TCGA-characterized tumor types.
  • Summaries of major discoveries, including driver mutations, genomic alterations, and molecular subtypes for each tumor.

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Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
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Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

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Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
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Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

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Related Experiment Videos

Last Updated: Feb 12, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
08:00

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

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Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

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Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
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Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

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Conclusions:

  • The TCGA program has significantly advanced our understanding of cancer at a genomic level.
  • This resource serves as a vital reference for cancer researchers and clinicians.