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Related Concept Videos

Ribosomes01:27

Ribosomes

77.2K
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
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Ribosomes01:27

Ribosomes

11.1K
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
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Coordination Number and Geometry02:57

Coordination Number and Geometry

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For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
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Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

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The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
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Coordination Compounds and Nomenclature02:54

Coordination Compounds and Nomenclature

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In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
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Related Experiment Video

Updated: Feb 12, 2026

Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation
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Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation

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Orchestrating Ribosomal Subunit Coordination to Control Stem Cell Fate.

Eesha Sharma1, Benjamin J Blencowe1

  • 1Donnelly Centre and Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.

Cell Stem Cell
|April 7, 2018
PubMed
Summary

The human transcription and splicing-associated factor (HTATSF1) maintains stem cell fate by regulating ribosomal protein and RNA production. This study clarifies how HTATSF1 controls stoichiometry for cell fate transitions.

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Area of Science:

  • Molecular Biology
  • Stem Cell Biology
  • Gene Regulation

Background:

  • Ribosomal component stoichiometry is crucial for cell fate transitions.
  • The underlying mechanisms for maintaining this balance are not well understood.
  • Understanding these mechanisms is key to controlling cell differentiation and development.

Purpose of the Study:

  • To investigate the role of the transcription and splicing-associated factor HTATSF1 in stem cell fate.
  • To elucidate how HTATSF1 influences ribosomal component production.
  • To understand the regulatory pathways controlling cell fate transitions.

Main Methods:

  • The study by Corsini et al. (2018) likely involved molecular biology techniques.
  • Investigated the function of HTATSF1 in stem cell models.
  • Analyzed the regulation of ribosomal protein and RNA production.

Main Results:

  • HTATSF1 was identified as a key regulator of stem cell fate.
  • HTATSF1 coordinately controls both ribosomal protein and RNA production.
  • This coordinated regulation is essential for maintaining stem cell pluripotency and directing cell fate.

Conclusions:

  • HTATSF1 plays a critical role in maintaining stem cell fate by ensuring proper ribosomal stoichiometry.
  • The findings provide new insights into the molecular mechanisms governing cell fate decisions.
  • HTATSF1 represents a potential therapeutic target for regenerative medicine and cancer research.