Related Experiment Video

Updated: Feb 12, 2026

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

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Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.

Ryo Yamamoto1, Adam C Wilkinson2, Jun Ooehara3

  • 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA, USA; Department of Genetics, Stanford University, Stanford, CA, USA; Division of Stem Cell Therapy, Center for Stem Cell Biology and Regeneration Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

Cell Stem Cell
|April 7, 2018
PubMed
Summary

Aging dramatically increases myeloid-restricted repopulating progenitors (MyRPs) and reveals latent hematopoietic stem cells (HSCs) in mice. These findings challenge traditional views of HSC aging and function.

Keywords:
HSCagingclonal analysishematopoiesishematopoietic stem cellmultipotencyself-renewalsingle cellstem cell aging

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