Related Experiment Video
Updated: Feb 12, 2026
Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Synthesis, characterization and antifungal efficacy of chitosan derivatives with triple quaternary ammonium groups
Weixiang Liu1, Yukun Qin2, Song Liu2
1CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Abstract:
A novel type of water soluble chitosan derivatives (TQCSPX) were synthesized including 3-aminopyridine (TQCSP1) and 3-Amino-4-methylpyridine (TQCSP2). The theoretical structures of TQCSPX were calculated by Gaussian 09 and confirmed by FT-IR, 1H NMR, 13C NMR, elemental analysis and XRD. The antifungal properties of TQCSPX against Phytophthora capsici (P. capsici), Rhizoctonia solani (R. solani), Fusarium oxysporum (F. oxysporum) and Fusarium solani (F. solani) were evaluated at concentrations ranging from 0.2mg/mL to 0.8mg/mL. Antifungal results indicated that the derivatives have significantly enhanced antifungal activity after quaternized compared with the original chitosan (CS). Moreover, TQCSP1 inhibited the growth of P. capsici with inhibitory indices of 91.94% at 0.8mg/mL. The experimental results demonstrated that the increasing number of the positive charge would improve the antifungal efficiency of chitosan, which may provide a novel direction for the development of fungicides.
Related Concept Videos
01:29Self-Efficacy
01:06Scalar and Vector Triple Products
The scalar triple product is the dot product of a vector with the cross product of two vectors....
01:15Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
02:17Synthesis and Decomposition Reactions
01:59Lagging Strand Synthesis
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
02:36Transfer RNA Synthesis
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...