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Neurodevelopmental assessment of HIV-exposed uninfected and early-treated HIV-infected children: study protocol

Renate Strehlau1, Tamryn van Aswegen2, Joanne Potterton2,3

  • 1Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. renate.strehlau@wits.ac.za.

BMC Research Notes
|April 8, 2018
PubMed

Insights

Early childhood stimulation programs combined with antiretroviral treatment (ART) show promise in improving neurodevelopmental outcomes for infants born with HIV in Sub-Saharan Africa.

Area of Science:

  • Global child development
  • Pediatric infectious diseases
  • Public health interventions

Background:

  • Sub-Saharan Africa faces a high burden of developmental delays in children, exacerbated by HIV and environmental challenges.
  • Early childhood developmental stimulation programs offer a potential strategy to improve outcomes for at-risk children.

Purpose of the Study:

  • To evaluate the impact of an early childhood stimulation program combined with antiretroviral treatment (ART) on neurodevelopmental outcomes in HIV-infected neonates.
  • To compare neurodevelopmental outcomes between HIV-infected infants receiving the intervention and those not receiving it.
  • To explore associations between neurodevelopment, environmental factors, and parental stress.

Main Methods:

  • A non-randomized controlled intervention study conducted in Johannesburg, South Africa.
  • HIV-positive neonates received ART and a tailored stimulation program throughout their first year.
  • Neurodevelopment was assessed at 12 months using the Bayley Scales of Infant and Toddler Development (BSID-III).

Main Results:

  • (Results not yet available as study is ongoing/recently initiated)

Conclusions:

  • The study aims to determine if early intervention with ART and stimulation can positively influence neurodevelopment in HIV-infected infants.
  • Findings will inform the development of targeted interventions to mitigate developmental risks associated with pediatric HIV in resource-limited settings.
Abstract

Keywords:
Early antiretroviral treatmentEarly childhood developmentHIV

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