Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

788
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
788
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

616
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
616
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.8K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.8K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.5K
4.5K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

3.2K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
3.2K
Pulmonary Ventilation: Inhalation01:24

Pulmonary Ventilation: Inhalation

8.4K
Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing healthcare-associated infections in critically ill children with burn injury.

Minerva anestesiologica·2026
Same author

Puffy infant suffering from respiratory distress: a clue for visual diagnosis.

Archives of disease in childhood·2026
Same author

Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.

Intensive care medicine·2026
Same author

Anesthesia and medical cannabis: an integrated approach.

Minerva anestesiologica·2026
Same author

Definition and prognostic value of response to prone positioning in ARDS: a systematic review and meta-analysis.

Critical care (London, England)·2026
Same author

Analgosedation During the Use of Non-Invasive Respiratory Supports: A Synthesis of Clinical Evidence and Best Practices.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Feb 12, 2026

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

21.1K

Comparative bench study evaluation of different infant interfaces for non-invasive ventilation.

Giorgio Conti1, Giorgia Spinazzola1, Cesare Gregoretti2

  • 1Intensive Care and Anaesthesia Department and Ventilab, Catholic University of Rome, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.

BMC Pulmonary Medicine
|April 8, 2018
PubMed
Summary

The endotracheal tube (ET) demonstrated superior patient-ventilator interaction and performance compared to nasal masks in infants with acute respiratory failure. While the Respireo mask showed a trend toward increased tidal volume, its overall efficiency was similar to the FPM mask.

Keywords:
Acute respiratory failureBench testInfant maskMechanical ventilationNon invasive ventilationPatient-ventilator interaction

More Related Videos

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
09:24

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer

Published on: September 13, 2018

9.5K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.1K

Related Experiment Videos

Last Updated: Feb 12, 2026

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

21.1K
3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
09:24

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer

Published on: September 13, 2018

9.5K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.1K

Area of Science:

  • Pediatric Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Infant acute respiratory failure (ARF) necessitates effective ventilatory support.
  • Patient-ventilator interaction is crucial for optimizing outcomes in infants receiving mechanical ventilation.
  • Evaluating novel interfaces for non-invasive ventilation (NIV) is essential for improving infant respiratory care.

Purpose of the Study:

  • To compare the patient-ventilator interaction and performance of a new nasal mask (Respireo) against an endotracheal tube (ET) and a conventional nasal mask (FPM).
  • To assess these interfaces during Pressure Support Ventilation (PSV) in an infant model of ARF.

Main Methods:

  • Utilized an active test lung (ASL 5000) simulating a 5.5 kg infant with ARF.
  • Ventilated the test lung using a standard ICU ventilator in PSV mode with three interfaces: Respireo, ET, and FPM.
  • Simulated respiratory rates of 50 and 60 breaths/min with minimal air leaks.

Main Results:

  • The ET exhibited significantly shorter inspiratory trigger and pressurization times compared to both nasal masks.
  • The FPM demonstrated the shortest expiratory trigger delay.
  • The Respireo mask showed a trend toward increased tidal volume delivery compared to the FPM, with lower inspiratory pressure-time product and trigger pressure drop than the ET.

Conclusions:

  • The endotracheal tube (ET) provided superior patient-ventilator interaction and performance in this infant ARF model.
  • The Respireo nasal mask, despite a larger internal volume, showed comparable efficiency to the FPM mask in terms of patient-ventilator interaction.
  • Further research may explore optimizing nasal mask design for improved infant NIV.