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Updated: Feb 12, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
858
CD109 and squamous cell carcinoma
Ruixia Qi1,2, Fengyun Dong2, Qiang Liu2
1Taishan Medical College, Tai'an, Shandong, China.
Journal of Translational Medicine
|April 8, 2018
Summary
Squamous cell carcinoma (SCC) shows high metastasis. CD109, a cell-surface glycoprotein, is highly expressed in SCCs and may drive cancer progression, emerging as a potential biomarker and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Squamous cell carcinoma (SCC) is characterized by high metastatic potential and poor patient prognosis.
- CD109, a cell-surface glycoprotein, has recently gained attention in SCC research.
- Elevated CD109 expression is frequently observed in human SCCs across various organs.
Purpose of the Study:
- To review the expression patterns of CD109 in different types of SCC.
- To elucidate the molecular mechanisms by which CD109 influences SCC pathogenesis.
- To highlight CD109 as a potential diagnostic biomarker and therapeutic target for SCC.
Main Methods:
- Literature review of studies investigating CD109 expression in SCC.
- Analysis of reported molecular mechanisms involving CD109 in cancer progression.
- Synthesis of current knowledge on CD109's role in SCC pathogenesis.
Main Results:
- CD109 is consistently overexpressed in human SCCs from multiple organ sites.
- Evidence suggests CD109 plays a significant role in promoting SCC progression and metastasis.
- The precise molecular functions of CD109 in SCC pathogenesis are under active investigation.
Conclusions:
- CD109 is a promising biomarker for SCC diagnosis and prognosis.
- Targeting CD109 may offer a novel therapeutic strategy for managing SCC.
- Further research is warranted to fully understand and exploit CD109's role in SCC.
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