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Related Concept Videos

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Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The barriers to effective communication also include cultural barriers, semantic barriers, gender barriers, and time constraints.
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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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Articles linked to this work by shared authors, journal, and citation graph.

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Expression and ultrastructural localization of plasmin(ogen) in the terminally differentiated layers of normal human epidermis.

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Fragility of epidermis in newborns, children and adolescents.

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Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and polymeric nanocapsules: A comparative study.

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Measurement, analysis and prediction of topical UV filter bioavailability.

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Related Experiment Video

Updated: Feb 12, 2026

An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model
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[The epidermal barrier].

R Abdayem1, M Haftek1

  • 1EA4169 « Aspects fondamentaux, cliniques et thérapeutiques de la fonction barrière cutanée », SFR Lyon-Est Santé, Inserm US 7, CNRS UMS 3453, Faculté de médecine et de pharmacie, Université Lyon 1, 8, avenue Rockefeller, 69373 Lyon, France.

Annales De Dermatologie Et De Venereologie
|April 8, 2018
PubMed
Summary

The skin

Area of Science:

  • Dermatology
  • Immunology
  • Cell Biology

Background:

  • The skin's epidermis is crucial for environmental interaction.
  • It comprises three key defensive systems: photoprotection, immune defense, and the stratum corneum barrier.

Purpose of the Study:

  • To detail the multifaceted functions of the epidermal barrier.
  • To explain the mechanisms of photoprotection, immune surveillance, and permeability regulation.

Main Methods:

  • Review of existing literature on epidermal structure and function.
  • Analysis of the roles of melanocytes, Langerhans cells, and keratinocytes.

Main Results:

  • The epidermis employs melanin and urocanic acid for UV protection.
Keywords:
Barrière cutanéeEpidermisPhotoprotectionSkin barrierStratum corneumÉpiderme

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  • Innate and adaptive immune responses are initiated by specialized cells.
  • The stratum corneum provides a physical and chemical permeability barrier.

    • Conclusions:

    • The epidermal barrier is a dynamic, constantly renewing system.
    • It exhibits remarkable adaptability to environmental changes.