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Systemic inflammatory disorders in patients admitted for aseptic meningitis

Marine Boudot de la Motte1, Rachid Abbas1, Fanny Jouan1

  • 1Bichat Hospital, Paris, France.

Clinical Medicine (London, England)
|April 8, 2018
PubMed

Insights

Identifying systemic inflammatory disorders (SIDs) in patients with acute aseptic meningitis is crucial. Clinical indicators, including neurological and extraneurological signs, significantly improve SID detection in these patients.

Area of Science:

  • Neurology
  • Rheumatology
  • Internal Medicine

Background:

  • Acute meningitis can be the initial presentation of underlying systemic inflammatory disorders (SIDs).
  • Early identification of SIDs in meningitis patients is essential for timely and appropriate management.

Purpose of the Study:

  • To identify clinical indicators for systemic inflammatory disorders (SIDs) in patients presenting with acute aseptic meningitis.
  • To improve the diagnostic yield of SIDs in patients hospitalized for acute aseptic meningitis.

Main Methods:

  • Retrospective analysis of patients hospitalized for acute aseptic meningitis over a 4-year period.
  • Exclusion of patients with neoplastic meningitis.
  • Systematic recording of extraneurological signs and application of international criteria for SID diagnosis.

Main Results:

  • Out of 43 analyzed patients, 23 (53.5%) had an underlying SID, predominantly sarcoidosis and Behçet's disease.
  • Logistic regression revealed a 93.7% probability of SID in patients with both neurological and extraneurological signs.
  • Conversely, patients with neither neurological nor extraneurological signs had only a 14.9% probability of SID.

Conclusions:

  • Clinical assessment incorporating both neurological and extraneurological signs is valuable for identifying patients with acute aseptic meningitis caused by SIDs.
  • This approach aids in the early detection and management of systemic inflammatory disorders presenting as meningitis.
Keywords:
Aseptic meningitisdiagnosishospitalised patientsinternal medicinesystemic inflammatory disorders

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