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Related Experiment Videos

Iohexol and ioxaglate in peripheral angiography.

M G Stiris1, F Laerum

  • 1Department of Radiology, Aker University Hospital, Oslo, Norway.

Acta Radiologica (Stockholm, Sweden : 1987)
|November 1, 1987
PubMed
Summary

This study compared two contrast media for lower limb arterial insufficiency. Ioxaglate caused less pain and had a smaller effect on blood pressure compared to iohexol, with no carry-over effects observed.

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Area of Science:

  • Radiology
  • Vascular Imaging
  • Pharmacology

Background:

  • Contrast media are essential for vascular imaging.
  • Low-osmolar contrast media reduce patient discomfort.
  • Comparing ionic and non-ionic contrast media is important for patient safety.

Purpose of the Study:

  • To evaluate carry-over effects of iohexol and ioxaglate.
  • To assess patient discomfort (pain, heat) during arterial injection.
  • To determine the impact of contrast media on peripheral blood pressure.

Main Methods:

  • Double-blind, cross-over trial design.
  • 107 patients with lower limb arterial insufficiency.
  • Comparison of iohexol and ioxaglate at 300 mg I/ml.

Main Results:

  • No significant carry-over effects were observed between contrast media.
  • Ioxaglate (ionic, low-osmolar) resulted in less injection pain and heat sensation than iohexol (non-ionic, low-osmolar).
  • Ioxaglate demonstrated a lesser effect on systemic blood pressure compared to iohexol.

Conclusions:

  • Ioxaglate is a well-tolerated contrast medium for lower limb angiography.
  • Ioxaglate offers advantages over iohexol regarding patient comfort and hemodynamic stability.
  • Further research may explore long-term outcomes with these agents.

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