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Updated: Feb 12, 2026
Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Management of leaking tracheoesophageal puncture with hyaluronic acid injection
Kevin Twomey1, Belinda Lehn1,2, Sarju Vasani1
1Department of Ear, Nose, and Throat Surgery, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, 4029, Australia.
Background:
Tracheoesophageal puncture (TEP) with voice prosthesis is a widely used technique for voice restoration in laryngectomy and pharyngolaryngectomy patients. Complications include leakage around the prosthesis or a persistent TEP postremoval of the prosthesis.
Methods:
We describe a method for managing leakage around voice prosthesis or persistent TEP using hyaluronic acid injection. We also present a retrospective audit of our practice.
Results:
This study had 8 patients who were treated over a 32-month period. All cases had immediate cessation of salivary leak. Duration of efficacy was variable. Five of the 8 cases had permanent resolution of their symptoms after multiple injections. Two cases of persistent TEP were treated surgically after multiple injections. One patient with peripheral leakage continues to have regular injections.
Conclusion:
Hyaluronic acid injection in the treatment of persistent TEP or peripheral leak around a voice prosthesis is a useful treatment option to provide immediate and occasionally long-lasting relief from symptoms.
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