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Remnant-like particles and coronary artery disease in familial hypercholesterolemia

Hayato Tada1, Masa-Aki Kawashiri1, Atsushi Nohara1

  • 1Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 8, 2018
PubMed

Insights

Remnant-like particle cholesterol (RLP-C) is linked to coronary artery disease (CAD) in familial hypercholesterolemia (FH) patients. While RLP-C correlates with triglycerides, its independent association with CAD severity requires further investigation.

Area of Science:

  • Cardiology
  • Lipid Metabolism
  • Genetics

Background:

  • Remnant-like particle cholesterol (RLP-C) is a known risk factor for coronary artery disease (CAD) in the general population.
  • Limited data exist on the association between RLP-C and CAD specifically in patients with familial hypercholesterolemia (FH).

Purpose of the Study:

  • To investigate the association between serum RLP-C levels and the presence and severity of CAD in patients diagnosed with FH.

Main Methods:

  • A cohort of 282 FH patients (144 males, mean age 41 years) had their serum RLP-C levels measured.
  • Baseline characteristics, lipid profiles, cardiovascular risk factors, and the presence of CAD were assessed.
  • Logistic regression analysis was performed, adjusting for multiple confounding variables.

Main Results:

  • Serum RLP-C levels showed a significant positive correlation with serum triglyceride (TG) levels (r=0.631, p<0.001).
  • Higher RLP-C tertiles were associated with a greater number of diseased coronary arteries (p<0.001 trend).
  • Adjusted logistic regression indicated RLP-C was significantly associated with CAD (OR: 1.08, p=0.046), but this association was nullified when TG levels were included. Lipoprotein (a) [Lp(a)] remained independently associated with CAD (OR: 1.02, p=0.015).

Conclusions:

  • Serum RLP-C levels are significantly associated with both the presence and severity of CAD in FH patients.
  • The independent clinical utility of RLP-C measurement, beyond that of TG, warrants further evaluation in this population.
Abstract

Keywords:
Familial hypercholesterolemiaLDL receptorProprotein convertase subtilisin/kexin type 9Remnant-like particleTriglyceride

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