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Methods to Test Visual Attention Online
Published on: February 19, 2015
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Homozygous LAMC3 mutation links to structural and functional changes in visual attention networks
Buse M Urgen1, Yasemin Topac2, F Seyhun Ustun1
1National Magnetic Resonance Research Center and Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Turkey; Graduate School of Engineering and Science, Neuroscience Program, Bilkent University, Ankara, Turkey.
Neuroimage
|April 8, 2018
Summary
Mutations in the LAMC3 gene cause brain abnormalities impacting visual attention. This study reveals that LAMC3 gene mutations affect distributed neural networks, particularly those involved in visuo-spatial attention.
Area of Science:
- Neuroscience
- Genetics
- Ophthalmology
Background:
- The occipital lobe is crucial for visual perception.
- LAMC3 gene mutations are linked to occipital cortical development abnormalities.
- The impact of these structural changes on visual behavior remains unclear.
Purpose of the Study:
- To investigate the behavioral and structural consequences of LAMC3 gene mutations on visual function.
- To assess the extent of structural changes in the brain and their correlation with visual attention deficits.
Main Methods:
- A patient with a homozygous LAMC3 gene mutation underwent visual screening tests (Leuven - Perceptual Organization Screening Test, Cortical Vision Screening Test) and a visual attention experiment.
- Voxel-based morphometry (VBM) was used to compare brain structure (cortical curvature, thickness, gray matter volume) between the patient and controls.
- Structural covariance analysis investigated anatomical connectivity between cortical areas.
Main Results:
- The patient exhibited predominant impairments in visuo-spatial attention.
- VBM analysis revealed significant structural changes in cortical regions associated with attentional functions.
- Structural connectivity analysis indicated alterations in networks supporting attention.
Conclusions:
- LAMC3 gene mutations affect brain regions beyond the occipital lobe.
- These mutations primarily impact visual functions reliant on distributed neural networks, such as visuo-spatial attention.
Keywords:
Cortical organizationLAMC3 mutationStructural covariance analysisVisuo-spatial attentionVoxel-based morphometryMore Related Videos
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