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Nuclear receptors as potential drug targets in osteoarthritis

Margaret Man-Ger Sun1, Frank Beier1, Anusha Ratneswaran1

  • 1Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada N6A 5C1; Bone & Joint Institute, The University of Western Ontario, London, ON, Canada N6A 5C1.

Current Opinion in Pharmacology
|April 8, 2018
PubMed

Insights

Nuclear receptors are implicated in osteoarthritis development. Modulating these nuclear receptors may offer new therapeutic strategies for treating osteoarthritis, a leading cause of global disability.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Rheumatology

Background:

  • Osteoarthritis (OA) is a major global cause of disability.
  • Current treatments do not halt OA progression.
  • Nuclear receptors are emerging as key players in OA pathogenesis.

Purpose of the Study:

  • To review recent advances in understanding the role of nuclear receptors in OA.
  • To explore the therapeutic potential of targeting nuclear receptors for OA treatment.

Main Methods:

  • Literature review of recent studies on nuclear receptors and osteoarthritis.
  • Analysis of the role of nuclear receptors in OA onset and progression.
  • Evaluation of therapeutic implications of nuclear receptor modulators.

Main Results:

  • Growing evidence links various nuclear receptors to different forms of osteoarthritis.
  • Nuclear receptors represent a promising class of drug targets for OA.
  • Modulators of nuclear receptor activity show potential for novel OA treatment strategies.

Conclusions:

  • Nuclear receptors play significant roles in osteoarthritis pathophysiology.
  • Targeting nuclear receptors offers a promising avenue for developing disease-modifying OA drugs.
  • Further research into additional nuclear receptors is warranted for comprehensive OA treatment strategies.

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