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Updated: Feb 12, 2026

A Simple and Efficient Method to Detect Nuclear Factor Activation in Human Neutrophils by Flow Cytometry
Published on: April 9, 2013
Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes
F B Sall1, D Germini, A P Kovina
1UMR8126, Université Paris-Sud, CNRS, Institut de Cancérologie Gustave Roussy, Villejuif, 94805, France. vassetzky@igr.fr.
Abstract:
Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental factors including the Epstein-Barr and human immunodeficiency viruses, malaria-causing parasites (Plasmodium falciparum), and plant components (Euphorbia tirucalli latex) can trigger a reorganization of the nuclear architecture and DNA damage that together will facilitate the occurrence of deleterious chromosomal rearrangements.
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