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Structure and Functions of the Mediator Complex
E V Putlyaev1, A N Ibragimov, L A Lebedeva
1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia. yul.biogen@gmail.com.
Abstract:
Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.
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