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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
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This is the first step in diagnosing and managing asthma. It includes:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Related Experiment Video

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Acupuncture in a Rat Model of Asthma
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Obesity and asthma.

Ubong Peters1, Anne E Dixon1, Erick Forno2

  • 1Pulmonary and Critical Care Medicine, University of Vermont, Burlington, Vt.

The Journal of Allergy and Clinical Immunology
|April 9, 2018
PubMed
Summary

Obesity significantly worsens asthma in children and adults, increasing risks and reducing treatment effectiveness. Understanding obese asthma

Keywords:
Asthmametabolic syndromemicrobiomeobese asthmaobesity

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Area of Science:

  • Pulmonary Medicine
  • Metabolic Disorders
  • Pediatric Asthma Research

Background:

  • Obesity is a major public health issue, strongly linked to increased asthma risk and severity in both children and adults.
  • Obese individuals with asthma experience more symptoms, frequent exacerbations, diminished medication response, and poorer quality of life.
  • Obese asthma represents a complex syndrome with distinct phenotypes requiring further elucidation.

Purpose of the Study:

  • To examine the epidemiology and characteristics of obese asthma in pediatric and adult populations.
  • To analyze changes in lung function associated with obesity in asthmatic patients across different age groups.
  • To review key factors and mechanisms in obese asthma pathogenesis, including diet, microbiome, inflammation, metabolism, and genetics.

Main Methods:

  • Epidemiological analysis of obese asthma prevalence and characteristics.
  • Comparative assessment of lung function changes in obese pediatric and adult asthmatics.
  • Literature review and synthesis of pathogenetic mechanisms and contributing factors.
  • Evaluation of current evidence on weight loss interventions for obese asthma.

Main Results:

  • Obesity is a significant risk factor and disease modifier for asthma, impacting disease presentation and severity.
  • Obese asthmatics exhibit distinct clinical features, including increased symptom burden and exacerbation frequency.
  • Pathogenesis involves complex interactions of diet, microbiome, inflammatory and metabolic dysregulation, and genetic factors.
  • Weight loss interventions show potential but require further research for optimal application in obese asthma management.

Conclusions:

  • Obese asthma is a distinct clinical entity requiring tailored management strategies.
  • Further research into the multifaceted pathogenesis of obese asthma is crucial for developing effective treatments.
  • Understanding the role of weight loss is essential for improving outcomes in this patient population.