Alveolar and Bronchial Nitric Oxide in Chronic Obstructive Pulmonary Disease and Asthma-COPD Overlap

Exhaled nitric oxide (F_ENO) measurements differentiate COPD phenotypes from asthma-COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients.

This was an observational cross-sectional study recruiting ambulatory COPD patients. F_ENO was measured, differentiating alveolar (C_ANO) from bronchial (J_awNO) components using a multiple-flow technique. C_ANO and J_awNO values were compared between eosinophilic COPD patients (defined as ≥ 300 eosinophils/μL in peripheral blood test, or ≥ 2% eosinophils or ≥ 3% eosinophils), and a linear regression analysis was performed to determine clinical and biological variables related to these measurements.

73 COPD patients were included in the study. Eosinophil counts were associated with increased values of C_ANO and J_awNO (for the latter only the association with ≥ 300 or ≥ 3% eosinophils was significant). C_ANO was also associated with CRP, and J_awNO with smoking.

Patients with COPD and ACO characteristics show increased inflammation in the large and small airways. C_ANO and J_awNO are associated with clinical and biological variables.