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Updated: Feb 12, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Structure-based design and discovery of potent and selective KDM5 inhibitors

Zhe Nie1, Lihong Shi1, Chon Lai1

  • 1Celgene Corporation, 10300 Campus Point Drive, Suite 100, San Diego, CA 92121, USA.

Bioorganic & Medicinal Chemistry Letters
|April 9, 2018
PubMed

Keywords:
EpigeneticsHistone lysine demethylaseKDM5Structure-based designTri-methylated H3K4

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