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Duodenal epithelial atypia. A specific complication of hepatic arterial infusion chemotherapy
L Schuger1, T Peretz, E Goldin
1Department of Pathology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Cancer
|February 15, 1988
Abstract:
Severe duodenal lesions developed in five patients during hepatic arterial infusion (HAI) employing 5-floxuridine (FUDR) as the basic antineoplastic agent. These lesions comprised ulcerative as well as proliferative processes. Striking structural distortion with cellular pleomorphism of the affected duodenal mucosa were the histological hallmark in all cases. These lesions are a specific complication of HAI chemotherapy and should not be misinterpreted as malignancy.