Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Testosterone: Functions and Regulation

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...

Increasing Function

Increasing Function

An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The...

Integration of Rational Functions Using Partial Fractions

Integration of Rational Functions Using Partial Fractions

Rational functions are expressions written as the ratio of two polynomials, and their integrals are evaluated by simplifying the integrand into manageable parts. These functions are classified as proper or improper based on the degrees of the numerator and denominator.A rational function is proper when the degree of the numerator is less than the degree of the denominator. In this case, partial fraction decomposition is used to rewrite the function as a sum of simpler rational terms. The...

Partial Fractions

Partial Fractions

A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Exercise Stress Test

Exercise Stress Test

Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Umbilical Cord Blood-Derived Extracellular Vesicles Enhance Neurovascular Regeneration and Improve Erectile Function in a Mouse Model of Bilateral Cavernous Nerve Injury.

Andrology·2026

Same author

High-dose SFRP2 attenuates fibrosis and promotes angiogenesis via Wnt signaling modulation in diabetic erectile dysfunction.

Open life sciences·2026

Same author

Polychlorinated Biphenyl 138 Induces Toxicant-Associated Steatohepatitis via Hepatic Iron Overload and Adipose Inflammation.

Toxics·2025

Same author

A narrative review of the distribution and role of multipotent fibroblasts in penile tissue: implications for regenerative medicine and erectile dysfunction.

Translational andrology and urology·2025

Same author

Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration.

Scientific reports·2025

Same author

Bone morphogenetic protein 2 rescues neurogenic abnormalities and angiogenic factors in mice with bilateral cavernous nerve injury.

The journal of sexual medicine·2025

Search research articles

Related Experiment Video

Updated: Feb 12, 2026

Targeted Training of Ultrasonic Vocalizations in Aged and Parkinsonian Rats

Targeted Training of Ultrasonic Vocalizations in Aged and Parkinsonian Rats

Published on: August 8, 2011

Exercise training causes a partial improvement through increasing testosterone and eNOS for erectile function in

Dae Yun Seo¹, Sung Ryul Lee¹, Hyo Bum Kwak²

¹National Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea.

Experimental Gerontology

|April 9, 2018

Summary

Exercise training improved erectile function in aging rats by boosting testosterone and penile endothelial nitric oxide synthase (eNOS). This suggests exercise may be a viable therapy for age-related erectile dysfunction.

Keywords:

Aging Erectile function Exercise Penile tissue Testosterone

More Related Videos

A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches

A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches

Published on: October 18, 2024

An Innovative Running Wheel-based Mechanism for Improved Rat Training Performance

An Innovative Running Wheel-based Mechanism for Improved Rat Training Performance

Published on: September 19, 2016

Related Experiment Videos

Last Updated: Feb 12, 2026

Targeted Training of Ultrasonic Vocalizations in Aged and Parkinsonian Rats

Targeted Training of Ultrasonic Vocalizations in Aged and Parkinsonian Rats

Published on: August 8, 2011

A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches

A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches

Published on: October 18, 2024

An Innovative Running Wheel-based Mechanism for Improved Rat Training Performance

An Innovative Running Wheel-based Mechanism for Improved Rat Training Performance

Published on: September 19, 2016

Area of Science:

Reproductive biology
Aging research
Exercise physiology

Background:

Aging disrupts sex hormone balance and causes penile endothelial dysfunction, contributing to erectile dysfunction (ED).
Understanding protective mechanisms against age-related ED is crucial for developing therapeutic interventions.

Purpose of the Study:

To investigate if exercise training can prevent erectile dysfunction in aging rats.
To determine if exercise increases serum testosterone and penile endothelial nitric oxide synthase (eNOS) levels in aged rats.

Main Methods:

Young and middle-aged Sprague Dawley rats underwent 6 weeks of treadmill exercise.
Evaluated body composition, serum sex hormones, penile eNOS and alpha smooth muscle actin (α-SMA) levels, and intracavernous pressure (ICP).

Main Results:

Exercise training counteracted age-related increases in body weight and decreases in testicular mass.
Exercise significantly increased serum testosterone levels in both young and middle-aged rats.
Exercise preserved penile eNOS and p-eNOS protein levels and increased α-SMA and maximal ICP in middle-aged rats.

Conclusions:

Exercise training enhances erectile function in aged rats via increased testosterone and improved penile endothelial function.
Exercise-induced activation of eNOS and increased testosterone contribute to its therapeutic potential for age-related erectile dysfunction.