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Regulation and function of avian selenogenome
Shuping Li1, Fei Gao1, Jiaqiang Huang1
1Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China.
Biochimica Et Biophysica Acta. General Subjects
|April 9, 2018
Summary
Avian selenogenome and selenoproteome are crucial for chick health. Understanding these, including 24 selenoproteins, aids in preventing diseases linked to selenium deficiency.
Area of Science:
- Avian nutrition and molecular biology.
- Biochemistry and comparative genomics.
Background:
- Selenium (Se) is vital for avian health.
- Se/vitamin E deficiency causes exudative diathesis, pancreatic atrophy, and muscular dystrophy in chicks.
Purpose of the Study:
- To review the avian selenogenome and selenoproteome.
- Analyze their evolution, regulation, function, and relation to Se deficiency diseases.
Main Methods:
- Literature review and analysis.
- Comparative genomics of avian and mammalian selenoproteins.
Main Results:
- 24 selenoproteins identified in chicks, including avian-specific SELENOU and SELENOP2.
- Expression of selenoprotein genes responds to dietary Se.
- Pathogenesis of deficiency diseases linked to selenoprotein dysfunction in redox balance.
Conclusions:
- Avian selenoprotein repertoire differs from mammals.
- Dietary selenium significantly impacts selenoprotein gene expression.
- Further research with gene knockout models is needed for precise functional characterization.
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