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CRP genetic variants are associated with mortality and depressive symptoms in chronic heart failure patients

S Kittel-Schneider1, M Kaspar2, D Berliner3

  • 1Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital of Frankfurt, Frankfurt, Germany; Comprehensive Heart Failure Center, University Hospital of Würzburg, Würzburg, Germany.

Brain, Behavior, and Immunity
|April 9, 2018
PubMed

Insights

Certain genetic variations in the C-reactive protein (CRP) gene are linked to higher mortality risk and increased depressive symptoms in heart failure (HF) patients. These findings suggest inflammation may connect HF prognosis and depression.

Area of Science:

  • Cardiology
  • Genetics
  • Psychiatry

Background:

  • Heart failure (HF) is a complex condition influenced by genetic and other factors.
  • Inflammatory mechanisms and depressive symptoms are increasingly recognized in HF pathogenesis and outcomes.
  • Depression is prevalent in HF patients and acts as a risk factor for cardiovascular disease.

Purpose of the Study:

  • To investigate the association between genetic variants of CRP and IL-6 and mortality in HF patients.
  • To explore the relationship between CRP and IL-6 genetic variants, CRP/IL-6 blood levels, and depressive symptoms.

Main Methods:

  • Analyzed blood levels of C-reactive protein (CRP) and Interleukin-6 (IL-6) in 936 heart failure patients.
  • Examined single nucleotide polymorphisms (SNPs) in the CRP and IL6 genes for their impact on mortality.
  • Assessed depressive symptoms using the PHQ-9 scale.

Main Results:

  • Recessive genotypes of two CRP gene SNPs (rs1800947 and rs11265263) were associated with significantly higher mortality risk.
  • These CRP variants correlated with elevated CRP blood levels and increased depressive symptoms.
  • No significant association was found between IL-6 gene variants and mortality.

Conclusions:

  • Less common CRP genetic variants may be linked to increased mortality, depressive symptoms, and CRP levels in HF patients.
  • The inflammatory system might serve as a link between poor HF prognosis and depressive symptoms.
  • Further research into CRP genetics could elucidate pathways connecting inflammation, HF outcomes, and depression.
Abstract

Keywords:
C-reactive proteinHeart failureInterleukin-6Major depressionSingle nucleotide polymorphism

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