CYP1A1 gene polymorphisms modify the association between PM₁₀ exposure and lung function.

Area of Science:

• Environmental Epidemiology
• Genetic Epidemiology
• Pulmonary Medicine

Background:

• Air pollution, specifically particulate matter (PM10), is linked to adverse effects on lung function.
• Genetic factors are known to modify the relationship between environmental exposures and health outcomes.

Purpose of the Study:

• To investigate whether CYP1A1 gene polymorphisms modify the impact of PM10 exposure on lung function in Korean adults.
• To identify specific CYP1A1 single nucleotide polymorphisms (SNPs) associated with PM10-related lung function changes.

Main Methods:

• Utilized health check-up data from 1817 Korean men.
• Assessed annual mean ambient PM10 concentrations.
• Analyzed three selected CYP1A1 gene SNPs and their interaction with PM10 on lung function parameters (FEV1, FVC).

Main Results:

• Significant interactions between CYP1A1 SNPs and PM10 exposure were found for FEV1 and FVC.
• Carriers of minor alleles in CYP1A1 SNPs showed increased susceptibility to PM10-induced lung function decline.
• PM10 was significantly associated with reduced FEV1 in individuals with heterozygous or homozygous alternate genotypes, but not in homozygous reference genotype groups.

Conclusions:

• The adverse association between PM10 exposure and lung function decline in Korean men is partly influenced by functional variants in the CYP1A1 gene.
• CYP1A1 gene polymorphisms play a role in modulating individual susceptibility to air pollution's effects on respiratory health.