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Global epidemiology and patterns of cerebral venous thrombosis: a systematic review and meta-analysis protocol

Celestin Danwang1, Temgoua Ngou Mazou2, Joël Noutakdie Tochie1

  • 1Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

BMJ Open
|April 9, 2018
PubMed

Insights

This systematic review synthesizes global data on cerebral venous thrombosis (CVT), a cause of stroke in young people. It aims to provide a comprehensive overview of CVT epidemiology, risk factors, and outcomes.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Epidemiology

Background:

  • Cerebral venous thrombosis (CVT) is a significant cause of stroke, particularly in pediatric and young adult populations.
  • Existing epidemiological data on CVT are limited, hindering a full understanding of its global burden.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis of global data on cerebral venous thrombosis (CVT).
  • To critically synthesize prevalence, incidence, risk factors, anatomical patterns, diagnostic/therapeutic delays, and mortality rates of CVT.
  • To present findings stratified by country income level.

Main Methods:

  • Systematic search of MEDLINE, EMBASE, and ISI Web of Science databases (1990-2017).
  • Screening of abstracts, study selection, data extraction, and risk of bias assessment.
  • Random effects meta-analysis for homogenous studies, with funnel plot and Egger's test for publication bias.

Main Results:

  • Data synthesis on CVT prevalence, incidence, and associated risk factors.
  • Analysis of anatomical patterns and delays in diagnosis and treatment.
  • Evaluation of CVT mortality rates globally, comparing high-income vs. low/middle-income countries.

Conclusions:

  • This review will provide crucial data for assessing the global impact of CVT.
  • Findings are expected to inform clinical practice and public health strategies for stroke prevention and management.
  • The study will be published in a peer-reviewed journal.
Abstract

Keywords:
cerebral veinsepidemiologythrombosis

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