Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

801
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
801
Fixed Action Patterns01:06

Fixed Action Patterns

17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Patterns of Fever01:26

Patterns of Fever

4.0K
Before understanding the types and patterns of fever, it is essential to know its phases.
4.0K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.6K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.6K
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

1.5K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Real-Time Clinical Decision Support System, for Mild Cognitive Impairment Detection, Based on a Hybrid Neural Architecture.

Computational and mathematical methods in medicine·2021
Same author

[Pemphigoid and dementia].

Revista espanola de geriatria y gerontologia·2019
Same author

[Inflammation and oxidation: predictive and/or causative factors].

Revista espanola de geriatria y gerontologia·2016
Same author

[Longitudinal analysis of nutrition parameters in a cohort of elderly people with and without dementia].

Revista espanola de geriatria y gerontologia·2015
Same author

[Genetics and Alzheimer's disease: a population at risk].

Revista espanola de geriatria y gerontologia·2012
Same author

Blisters in a nursing home: bullous pemphigoid more often than we think?

Journal of the American Geriatrics Society·2004

Related Experiment Video

Updated: Feb 12, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.3K

[Patterns of brain ageing].

Carlos Fernández Viadero1, Rosario Verduga Vélez2, Dámaso Crespo Santiago3

  • 1Servicio de Psiquiatría, Hospital Universitario Marqués de Valdecilla, Servicio Cántabro de Salud, Santander, España; Biogerontología, Departamento de Anatomía y Biología Celular, Universidad de Cantabria, Santander, España.

Revista Espanola De Geriatria Y Gerontologia
|April 10, 2018
PubMed
Summary

Brain aging involves changes in neuroplasticity and neural growth factors, but neuron numbers remain stable. Physical exercise may mitigate age-related cognitive decline and neurodegeneration.

Keywords:
AgeingAnimal modelsBrainCerebroEnvejecimientoInsulinInsulinaModelos animalesNeuroplasticidadNeuroplasticityNeurotransmisoresNeurotransmitters

More Related Videos

Cross-Modal Multivariate Pattern Analysis
13:51

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

20.5K
Understanding Cerebellar Pattern Formation
13:18

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

5.5K

Related Experiment Videos

Last Updated: Feb 12, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.3K
Cross-Modal Multivariate Pattern Analysis
13:51

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

20.5K
Understanding Cerebellar Pattern Formation
13:18

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

5.5K

Area of Science:

  • Neuroscience
  • Gerontology
  • Molecular Biology

Background:

  • Aging brains exhibit adaptive neuroplasticity, yet show altered neurotransmission and growth factor expression.
  • Morphometric changes like volume loss are linked to neuroplasticity and neuropil alterations.
  • While aged brains can show volume loss, neuroimaging reveals significant individual variation, with stable neuron numbers in most regions.

Purpose of the Study:

  • To review the multifaceted changes in the aging brain, focusing on neuroplasticity, molecular alterations, and the impact of insulin-like growth factor.
  • To explore the potential neuroprotective effects of insulin in the context of aging and neurodegeneration.
  • To synthesize findings from animal models and human studies on brain aging.

Main Methods:

  • Literature review of animal models and human studies on brain aging.
  • Analysis of molecular, morphometric, and functional changes associated with aging.
  • Examination of the role of neural growth factors, Tau and beta-amyloid proteins, and insulin-like growth factor.

Main Results:

  • Neuroplasticity persists in aging, with synaptic and dendritic changes correlating more with brain activity than chronological age.
  • Abnormal Tau and beta-amyloid proteins are prevalent in elderly individuals without dementia, challenging their exclusive role as disease biomarkers.
  • Physical exercise shows potential benefits for molecular, functional, and cognitive aspects of brain aging.

Conclusions:

  • Brain aging is characterized by complex adaptations in neuroplasticity and molecular pathways, not uniform decline.
  • While certain proteins are associated with neurodegeneration, their presence alone in the elderly does not confirm disease.
  • Insulin-like growth factor and insulin may play crucial roles in neuroprotection during aging, warranting further investigation.