Related Experiment Video

Updated: Feb 12, 2026

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes
09:37

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes

Published on: June 19, 2015

9.5K

Novel class 1 integron (In1390) harboring blaGES-5 in a Morganella morganii strain recovered from a remote community

Quézia Moura1, Louise Cerdeira2, Miriam R Fernandes2

  • 1Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Diagnostic Microbiology and Infectious Disease
|April 10, 2018
PubMed

Insights

Antimicrobial resistance in Morganella morganii is often plasmid-mediated. A novel class 1 integron, In1390, carrying the blaGES-5 gene, was identified in a Morganella morganii isolate from the Amazon region.

Area of Science:

  • Microbiology
  • Genomics
  • Antimicrobial Resistance

Background:

  • Morganella morganii is an opportunistic pathogen.
  • Antimicrobial resistance in M. morganii is frequently linked to plasmids and class 1 integrons.

Purpose of the Study:

  • To report the characterization of a novel class 1 integron harboring the blaGES-5 gene in a M. morganii isolate.
  • To investigate the genetic basis of antimicrobial resistance in a M. morganii strain from a remote Amazonian community.

Main Methods:

  • Whole-genome sequencing of the M. morganii isolate.
  • Bioinformatic analysis to identify antimicrobial resistance genes and mobile genetic elements.
  • Integron and gene characterization.

Main Results:

  • Identification of the blaGES-5 gene, conferring resistance to beta-lactams.
  • Discovery of a novel class 1 integron, designated In1390, carrying the blaGES-5 gene.
  • Genomic context analysis revealed the integron's structure and potential mobility.

Conclusions:

  • This study reports the first identification of the blaGES-5 gene within a novel class 1 integron (In1390) in M. morganii.
  • The findings highlight the emergence and spread of antimicrobial resistance genes in remote geographical areas.
  • Genomic surveillance is crucial for understanding the evolution and dissemination of resistance mechanisms in clinically relevant bacteria.
Keywords:
BrazilCarbapenemaseGES-5IntegronsMorganella morganii

More Related Videos

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing06:16

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing

Published on: April 25, 2019

8.0K
Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

7.1K

Related Concept Videos

What are Populations and Communities?00:30

What are Populations and Communities?

Overview
38.0K
5-Number Summary01:04

5-Number Summary

In a dataset, the 5-number summary includes the minimum data value, the data value of the first quartile, the median data value or data value of the second quartile, the data value of the third quartile, and the maximum data value. These 5 data values can be visualized as a box and whisker plot.
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
5.7K
Drug Classes and Categories01:25

Drug Classes and Categories

Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
3.1K
Antibody Structure and Classes01:25

Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
9.3K
Community Based Intervention01:30

Community Based Intervention

Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
487
Thermal Strain01:19

Thermal Strain

Thermal strain is a concept that arises when we consider how temperature changes affect structures. Unlike the conventional assumption that structures remain constant under load, real-world scenarios often involve temperature fluctuations that can significantly impact these structures. Consider a homogeneous rod with a uniform cross-section resting freely on a flat horizontal surface. If the rod's temperature increases, the rod elongates. This elongation is proportional to the temperature...
2.9K