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5'-Hydroxy-5'-homoaristeromycin: Synthesis and antiviral properties
Qi Chen1, Chong Liu2, Terry L Bowlin3
1Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849-5312, United States; Department of Chemistry, Slippery Rock University, Slippery Rock, PA 16057, United States.
Bioorganic & Medicinal Chemistry Letters
|April 10, 2018
Abstract:
Synthetically combining the C-4' side-chain structural features of the antiviral candidates 5'-methylaristeromycin and 5'-homoaristeromycin into a diastereomeric pair of C-4' side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising effects towards HBV (6, 6.7 μM and 7, 7.74 μM) and HCMV (only 7, 0.72 μM). No other activity was found. Neither of the diastereomers was cytotoxic in the assays performed.