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Antonio Di Sabatino1, Marco Vincenzo Lenti1, Lisa Cammalleri2

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Summary
This summary is machine-generated.

Frailty impacts physical, psychological, and social health, increasing vulnerability. This review explores frailty's effects on gut health and the gut-brain axis, crucial for aging populations.

Keywords:
Alzheimer’s diseaseGut permeabilityInflamm-ageingMicrobiotaMultidimensional prognostic indexNeurodegenerationParkinson’s disease

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Area of Science:

  • Gerontology and Public Health
  • Gastroenterology
  • Neuroscience

Background:

  • Frailty is a growing public health concern in aging societies, characterized by multi-domain decline and increased vulnerability.
  • Frailty is often under-recognized clinically, with limited understanding of its impact on intestinal functions and gut microbiota.
  • Emerging evidence links gut-brain axis dysregulation in senescence to neuroinflammation, suggesting a role for gut health in neurodegenerative diseases.

Purpose of the Study:

  • To review current knowledge on the relationship between frailty and intestinal functions.
  • To explore the impact of frailty on gut microbiota composition.
  • To examine the role of the gut-brain axis in frailty and its potential implications for neurodegenerative disorders.

Main Methods:

  • Literature review synthesizing current research findings.
  • Analysis of studies investigating frailty's effects on the gastrointestinal system.
  • Exploration of the gut-brain axis in the context of aging and frailty.

Main Results:

  • Frailty significantly affects physical, psychological, and social domains, increasing vulnerability.
  • The impact of frailty on intestinal functions (immune response, permeability, absorption) and gut microbiota remains largely unexplored.
  • Perturbations in the gut-brain axis due to senescence may contribute to neuroinflammation.

Conclusions:

  • Understanding intestinal dysfunction in the elderly is vital for clarifying frailty-related risks of infection and inflammation.
  • Preserving gut permeability and mitigating frailty-associated microbiota changes may reduce susceptibility to neurodegenerative diseases.
  • Further research is needed to elucidate the complex interplay between frailty, gut health, and the gut-brain axis.