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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Sequences01:29

Sequences

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Sequences are fundamental mathematical objects consisting of ordered lists of numbers that follow a specific rule or pattern. Sequences are critical in various mathematical concepts, including calculus, series, and number theory. They can model real-world phenomena such as population growth, financial investments, and physical processes like the diminishing height of a bouncing ball.Each number in a sequence is referred to as a term. Typically, the terms are denoted as a1, a2, a3,…, where...
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Sanger Sequencing01:57

Sanger Sequencing

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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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Arithmetic Sequences01:30

Arithmetic Sequences

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An arithmetic sequence is a structured arrangement of numbers where each term is derived by adding a constant value, known as the common difference, to the previous term. This consistent pattern allows for the efficient computation of any term within the sequence as well as the cumulative sum of multiple terms. The formula for finding the nth term of an arithmetic sequence is:Here, aₙ represents the nth term of the sequence, a is the first term, d is the common difference, and n is the...
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Targeted DNA Methylation Analysis by Next-generation Sequencing
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Targeted therapy according to next generation sequencing-based panel sequencing.

Motonobu Saito1, Tomoyuki Momma1, Koji Kono1

  • 1Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine.

Fukushima Journal of Medical Science
|April 10, 2018
PubMed
Summary

Next-generation sequencing (NGS) identifies genetic mutations for targeted cancer therapy. NGS-based panels efficiently detect multiple gene variants, guiding personalized treatment and clinical trial enrollment for improved patient survival.

Keywords:
clinical sequencinggene sequencing panelnext-generation sequencingpersonalized medicine

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Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Targeted therapy for actionable gene mutations offers superior outcomes to chemotherapy.
  • Next-generation sequencing (NGS) advances have revolutionized the identification of numerous genetic aberrations in cancer.

Purpose of the Study:

  • To highlight the role of NGS-based sequencing panels in identifying actionable mutations for personalized cancer therapy.
  • To emphasize the clinical utility of comprehensive genomic profiling for guiding treatment decisions and clinical trial matching.

Main Methods:

  • Utilizing NGS-based sequencing panels for simultaneous, multi-gene analysis of tumor somatic genome variants.
  • Employing comprehensive bioinformatics to interpret genetic aberrations including mutations, copy number alterations, and gene fusions.

Main Results:

  • NGS panels enable efficient and cost-effective identification of a wide range of genetic aberrations.
  • Sequencing results guide recommendations for targeted therapy, immunotherapy, or clinical trial participation.

Conclusions:

  • NGS-based sequencing panels are integral to modern oncology, facilitating personalized medicine.
  • The adoption of these panels in clinical practice supports tailored treatment strategies and enhances patient management for various cancers.