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Targeted therapy according to next generation sequencing-based panel sequencing

Motonobu Saito1, Tomoyuki Momma1, Koji Kono1

  • 1Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine.

Fukushima Journal of Medical Science
|April 10, 2018
PubMed

Insights

Next-generation sequencing (NGS) identifies genetic mutations for targeted cancer therapy. NGS-based panels efficiently detect multiple gene variants, guiding personalized treatment and clinical trial enrollment for improved patient survival.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Targeted therapy for actionable gene mutations offers superior outcomes to chemotherapy.
  • Next-generation sequencing (NGS) advances have revolutionized the identification of numerous genetic aberrations in cancer.

Purpose of the Study:

  • To highlight the role of NGS-based sequencing panels in identifying actionable mutations for personalized cancer therapy.
  • To emphasize the clinical utility of comprehensive genomic profiling for guiding treatment decisions and clinical trial matching.

Main Methods:

  • Utilizing NGS-based sequencing panels for simultaneous, multi-gene analysis of tumor somatic genome variants.
  • Employing comprehensive bioinformatics to interpret genetic aberrations including mutations, copy number alterations, and gene fusions.

Main Results:

  • NGS panels enable efficient and cost-effective identification of a wide range of genetic aberrations.
  • Sequencing results guide recommendations for targeted therapy, immunotherapy, or clinical trial participation.

Conclusions:

  • NGS-based sequencing panels are integral to modern oncology, facilitating personalized medicine.
  • The adoption of these panels in clinical practice supports tailored treatment strategies and enhances patient management for various cancers.
Keywords:
clinical sequencinggene sequencing panelnext-generation sequencingpersonalized medicine

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