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Related Concept Videos

Phase Transitions02:31

Phase Transitions

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Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
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Properties of Transition Metals02:58

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Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
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Cooperative Allosteric Transitions01:58

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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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Phase Transitions: Vaporization and Condensation02:39

Phase Transitions: Vaporization and Condensation

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The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules...
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Related Experiment Video

Updated: Feb 12, 2026

Studying TGF-&#946; Signaling and TGF-&#946;-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

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Jamming transitions in cancer.

Linda Oswald1, Steffen Grosser1, David M Smith2

  • 1University of Leipzig, Faculty of Physics and Earth Sciences, Debye Institute, Linnéstr. 5, 04103 Leipzig, Germany.

Journal of Physics D: Applied Physics
|April 10, 2018
PubMed
Summary

Tissues can behave as solids or liquids. Research shows a link between tissue unjamming transitions and cancer progression, impacting treatment strategies.

Keywords:
EMTcancercell mechanicscell migrationepithelialjammingmetastasis

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Area of Science:

  • Biophysics
  • Cancer Research
  • Cell Biology

Background:

  • Tissues traditionally viewed as liquids with properties like surface tension and viscosity.
  • Recent biophysical research focuses on conditions determining liquid-like or solid-like tissue behavior.
  • Concepts like cellular jamming and glassy tissues are now central to tissue mechanics research.

Purpose of the Study:

  • To review recent studies on tissue phase states, focusing on jamming transitions in cancer.
  • To explore the relationship between tissue mechanical properties and tumor progression.
  • To highlight the potential clinical implications of understanding tissue jamming in cancer metastasis.

Main Methods:

  • Review of recent scientific literature on tissue mechanics and cancer.
  • Analysis of studies investigating jamming transitions in cellular systems.
  • Examination of research linking cellular behavior to tumor progression and metastasis.

Main Results:

  • A connection has been identified between unjamming transitions and tumor progression.
  • Cancer cells' ability to metastasize is associated with changes in tissue mechanical states.
  • Understanding these phase transitions offers new perspectives on cancer behavior.

Conclusions:

  • The mechanical state of tissues, particularly jamming transitions, is crucial in understanding cancer metastasis.
  • This research could inform the development of novel surgical and therapeutic strategies for cancer patients.
  • Further investigation into tissue phase states may unlock new avenues for cancer treatment.