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Effect of Pregabalin Premedication on Emergence Agitation in Children after Sevoflurane Anesthesia: A Randomized

Hesham Mohamed Marouf1

  • 1Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Tanta University, Tanta, Egypt.

Anesthesia, Essays and Researches
|April 10, 2018
PubMed

Insights

Preoperative pregabalin effectively reduced emergence agitation (EA) and vomiting in pediatric patients after sevoflurane anesthesia. This intervention also lowered the need for pain medication without impacting recovery time.

Area of Science:

  • Pediatric Anesthesiology
  • Pharmacology
  • Surgical Recovery

Background:

  • Emergence agitation (EA) is a frequent complication in children following sevoflurane anesthesia.
  • Identifying effective interventions to mitigate EA is crucial for pediatric surgical care.

Purpose of the Study:

  • To investigate the efficacy of preoperative pregabalin in reducing emergence agitation in pediatric patients undergoing sevoflurane anesthesia.
  • To assess the impact of pregabalin on other postoperative outcomes, including pain, recovery time, and side effects.

Main Methods:

  • A prospective, randomized, double-blind, placebo-controlled study involving 60 children (aged 4-10 years) undergoing adenotonsillectomy.
  • Children received either pregabalin (1.5 mg/kg) or placebo syrup 30 minutes before surgery.
  • Postoperative emergence agitation scale (EAS), time to eye-opening, extubation, PACU stay, analgesic requirements, and complications were recorded.

Main Results:

  • The pregabalin group exhibited significantly lower emergence agitation scores (EAS) compared to the placebo group.
  • Patients receiving pregabalin required less paracetamol for postoperative pain management and experienced less vomiting.
  • There were no significant differences in the time to eye-opening, extubation time, or postanesthesia care unit (PACU) duration of stay between the groups.

Conclusions:

  • Preoperative administration of pregabalin is effective in decreasing emergence agitation, analgesic needs, and vomiting in pediatric patients after sevoflurane anesthesia for adenotonsillectomy.
  • Pregabalin does not adversely affect key recovery parameters such as time to eye-opening, extubation, or PACU length of stay.
Abstract

Keywords:
Childrenemergence agitationpregabalinsevoflurane

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