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Invasive fungal infection in immunocompetent trauma patients - A case series
Senthil Loganathan1, Gowtham A E Ajay1, U Thyagarajan1
1Department of Orthopaedics, Sri Ramachandra University, India.
Abstract:
Zygomycosis is the third leading cause of invasive fungal infection after candidiasis and aspergillosis. Although zygomycosis mostly affects immunocompromised individuals trauma may potentiate infection in immunocompetent individuals. The mortality rate of Zygomycosis is around 50% due to angioinvasion. Here we report a series of 5 cases of angio invasive fungal infection in immunocompetent individuals who sustained trauma in urban areas, out of which only one patient survived following high above knee amputation.
Insights
Trauma can lead to angioinvasive zygomycosis, a severe fungal infection, even in healthy individuals. This study highlights the high mortality rate and the critical role of amputation in survival for these rare cases.
Area of Science:
- Mycology
- Infectious Diseases
- Trauma Surgery
Background:
- Zygomycosis is a severe invasive fungal infection, ranking third after candidiasis and aspergillosis.
- While typically affecting immunocompromised individuals, trauma can precipitate zygomycosis in immunocompetent hosts.
- Angioinvasion in zygomycosis leads to a high mortality rate, approximately 50%.
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