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Updated: Feb 12, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

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Immune consequences of anti-angiogenic therapyin renal cell carcinoma

Klaudia K Brodaczewska1, Cezary Szczylik1,2,3, Claudine Kieda1

  • 1Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland.

Contemporary Oncology (Poznan, Poland)
|April 10, 2018
PubMed

Insights

Anti-angiogenic therapies for renal cell carcinoma (RCC) impact tumor vascularization and the immune microenvironment. Modulating angiogenesis may enhance immunotherapy effectiveness against this cancer.

Area of Science:

  • Oncology
  • Immunology
  • Vascular Biology

Background:

  • Renal cell carcinoma (RCC) is a highly vascularized tumor.
  • Current treatments primarily use anti-angiogenic therapies like tyrosine kinase inhibitors (TKIs) and anti-VEGF antibodies.
  • These therapies aim to inhibit tumor vascularization but also alter the tumor microenvironment.

Purpose of the Study:

  • To review the effects of anti-angiogenic treatments on the immune component of the RCC microenvironment.
  • To explore how angiogenesis modulation influences anti-cancer immunity.

Main Methods:

  • Literature review of studies on anti-angiogenic therapies in RCC.
  • Analysis of data on the impact of these therapies on tumor immunity.
  • Synthesis of current knowledge on angiogenesis modulation and immunotherapy.

Main Results:

  • Anti-angiogenic therapies, particularly TKIs, significantly modify the immune landscape within the RCC tumor microenvironment.
  • Evidence suggests that altering tumor vasculature impacts immune cell infiltration and function.
  • These modifications highlight the interplay between angiogenesis and anti-tumor immunity.

Conclusions:

  • Anti-angiogenic treatments have broader effects beyond vascularization, influencing the immune system.
  • Modulating angiogenesis presents a potential strategy for augmenting anti-cancer immunotherapy in RCC.
  • Further research is warranted to optimize combination strategies for improved patient outcomes.
Keywords:
angiogenesisrenal cell carcinomatyrosine kinase inhibitorsvessel normalisation

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