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Association between vitamin D and urinary tract infection in children
Abolfazl Mahyar1, Parviz Ayazi1, Sara Safari1
1Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Insights
Children with higher serum 25-hydroxyvitamin D (25(OH)D) levels showed a significant association with urinary tract infections (UTIs). This suggests vitamin D may play a role in UTI development.
Area of Science:
- Pediatrics
- Infectious Diseases
- Endocrinology
Background:
- Urinary tract infections (UTIs) are common in children.
- Vitamin D deficiency is prevalent globally and may impact immune function.
- The role of vitamin D in pediatric UTIs requires further investigation.
Purpose of the Study:
- To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and the occurrence of UTIs in children.
- To compare 25(OH)D levels in children diagnosed with UTI versus healthy controls.
Main Methods:
- A case-control study involving 70 children with UTI (cases) and 70 healthy children (controls).
- Participants aged 1 month to 12 years.
- Serum 25(OH)D levels were quantified using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- The mean serum 25(OH)D level was significantly higher in children with UTI (20.4±8.6 ng/mL) compared to healthy controls (16.9±7.4 ng/mL) (P=0.01).
- No significant difference in age or gender distribution was observed between the case and control groups (P=0.39 and P=0.24, respectively).
Conclusions:
- Serum 25(OH)D levels are associated with UTIs in children.
- Elevated 25(OH)D levels may indicate a role in UTI pathogenesis.
- Further research is warranted to elucidate the specific mechanisms of vitamin D in UTI prevention or progression.
Purpose:
The present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children.
Methods:
In this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed and compared between both groups.
Results:
Among 70 children with UTI (case group), 5 children (7.2%) were male and 65 (92.8%) were female. Among the healthy children (control group), 9 (12.8%) and 61 children (87.2%) were male and female, respectively (P=0.39). The mean±standard deviation of age in the case and control groups were 53.2±35.6 and 36.1±60.2 months, respectively (P=0.24). The mean level of serum 25(OH)D in the case group was significantly higher than that of the control group (20.4±8.6 ng/mL vs. 16.9±7.4 ng/mL, P=0.01).
Conclusion:
This study showed that there was a relationship between serum 25(OH)D levels and UTI in children. It seems that 25(OH)D plays a role in the pathogenesis of UTI.
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