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Prophylactic effect of riboflavin on pediatric migraine: a randomized, double-blind, placebo-controlled trial

Ahmad Talebian1,2, Babak Soltani2,3, Hamid Reza Banafshe4

  • 1M.D., Pediatric Neurologist, Professor, Department of Pediatrics, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

Electronic Physician
|April 10, 2018
PubMed

Insights

High-dose riboflavin significantly reduced migraine frequency and duration in children. Low-dose riboflavin showed no significant effect, indicating high-dose is a safe prophylactic option for pediatric migraine.

Area of Science:

  • Pediatric Neurology
  • Clinical Trial Research
  • Migraine Prophylaxis

Background:

  • Migraine is a common neurological disorder in children.
  • Prophylactic treatments aim to reduce migraine frequency, intensity, and duration.
  • Riboflavin (vitamin B2) is investigated for its potential prophylactic effects.

Purpose of the Study:

  • To evaluate the prophylactic efficacy of riboflavin in children suffering from migraine.
  • To compare the effects of low-dose and high-dose riboflavin against a placebo.

Main Methods:

  • A randomized clinical trial involving 90 children with migraine.
  • Participants were assigned to placebo, low-dose riboflavin, or high-dose riboflavin groups.
  • Outcomes (frequency, intensity, duration) were assessed at baseline and 12 weeks.

Main Results:

  • High-dose riboflavin significantly decreased migraine frequency and duration compared to placebo (p=0.000).
  • Low-dose riboflavin did not show significant reductions in frequency or duration versus placebo.
  • Neither low-dose nor high-dose riboflavin significantly reduced migraine intensity.

Conclusions:

  • High-dose riboflavin is a safe and effective prophylactic treatment for pediatric migraine.
  • It is well-tolerated and cost-effective for managing childhood migraines.
  • Further research may explore optimal dosing for intensity reduction.
Abstract

Keywords:
ChildrenMigraineProphylaxisRiboflavin

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