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Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes
Chi Wai Cheung1, Marten Leendert Ploeger1, Xile Hu1
1Laboratory of Inorganic Synthesis and Catalysis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne (EPFL) , ISIC-LSCI , BCH 3305 , Lausanne 1015 , Switzerland . Email: xile.hu@epfl.ch ; http://lsci.epfl.ch.
Abstract:
Aminocarbonylation of aryl halides is one of the most useful methods in amide synthesis, but nitroarenes have not been used as a nitrogen source in this method even though they are more economical and accessible than anilines. Reported here is the development of nickel catalysis for the first three-component reactions of aryl halides, Co2(CO)8, and nitroarenes under reductive conditions to produce aryl amides. A wide range of (hetero)aryl iodides and bromides as well as nitro(hetero)arenes are suitable reaction partners, and high functional group compatibility has been achieved. The method might be used for the streamlined synthesis of aryl amides.
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