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Effect of vitamins on Trichinella pseudospiralis Garkavi, 1972 infection in mice
1Institute of Parasitology, Czechoslovak Academy of Sciences, Ceské Budĕjovice.
Abstract:
The effects of vitamins A, B complex, E, and ADE on the eosinophilia, body weight, number of obtained larvae and distribution of larvae of Trichinella pseudospiralis were examined in mice. The increased eosinophilia started to appear in the majority of infected mice from day 7 p.i., the maximum being around day 21 p.i. The highest values of eosinophilia were observed in the mice after application of vitamin B complex. In spite of considerable individual differences, the greatest decrease in body weight occurred in mice receiving vitamins E and B complex. The greatest numbers of larvae were obtained from mice receiving vitamins E and B complex, which is proportional to the increase in eosinophilia. The numbers of muscle larvae in untreated mice and in those receiving vitamins ADE were approximately the same. The lowest numbers of larvae occurred in mice receiving vitamin A. In all mice groups the greatest numbers of larvae were localized in the left foreleg and diaphragm.
Insights
Vitamin B complex and vitamin E supplementation increased eosinophilia and Trichinella pseudospiralis larvae in mice. Vitamin A reduced parasite load, while vitamins E and B complex most impacted body weight.
Area of Science:
- Immunology
- Parasitology
- Nutritional Science
Background:
- Trichinella pseudospiralis is a parasitic nematode causing trichinellosis.
- Eosinophilia is a common host response to helminth infections.
- Nutritional status can influence host-parasite interactions.
Purpose of the Study:
- To investigate the impact of specific vitamin supplements (A, B complex, E, ADE) on the host's immune response and parasite burden in Trichinella pseudospiralis infected mice.
- To determine how vitamin supplementation affects eosinophilia, body weight, and larval distribution of T. pseudospiralis.
Main Methods:
- Mice were infected with Trichinella pseudospiralis.
- Mice received daily oral doses of vitamins A, B complex, E, or ADE.
- Eosinophil counts, body weight, and the number and distribution of muscle larvae were assessed post-infection.
Main Results:
- Vitamin B complex and vitamin E supplementation were associated with the highest eosinophil counts and greatest numbers of T. pseudospiralis larvae.
- Mice receiving vitamins E and B complex exhibited the most significant body weight decrease.
- Vitamin A supplementation resulted in the lowest number of larvae, comparable to untreated controls.
- Muscle larvae were predominantly found in the left foreleg and diaphragm across all groups.
Conclusions:
- Vitamin B complex and vitamin E may exacerbate the host immune response and increase T. pseudospiralis larval burden.
- Vitamin A supplementation shows potential for reducing T. pseudospiralis infection.
- Vitamin supplementation significantly influences the host's response to T. pseudospiralis infection, affecting both immunity and parasite load.