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High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
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The search for drug-targetable diagnostic, prognostic and predictive biomarkers in chronic graft-versus-host disease

Hong-Gang Ren1,2,3, Djamilatou Adom1,2,3, Sophie Paczesny1,2,3

  • 1a Department of Pediatrics , Indiana University , Indianapolis , IN , USA.

Expert Review of Clinical Immunology
|April 10, 2018
PubMed

Insights

Identifying biomarkers through omics technologies is vital for diagnosing and treating chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). These biomarkers aid drug development and patient management.

Area of Science:

  • Biomedical research
  • Translational medicine
  • Oncology

Background:

  • Chronic graft-versus-host disease (cGVHD) is a major complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT).
  • Effective diagnostic and prognostic tools are needed to manage cGVHD, a leading cause of late morbidity and mortality.
  • Omics technologies offer novel avenues for biomarker discovery in cGVHD.

Purpose of the Study:

  • To review omics-identified biomarkers critical for cGVHD target identification in drug development.
  • To summarize omics tools used for discovering cGVHD biomarkers.
  • To discuss challenges and therapeutic potential of identified biomarkers.

Main Methods:

  • Review of literature focusing on omics technologies (genomics, transcriptomics, proteomics, cytomics).
  • Identification of biomarkers verified in at least two independent cohorts.
  • Analysis of drug targetability and therapeutic potential of biomarkers.

Main Results:

  • Several omics-identified biomarkers for cGVHD have been discovered and verified.
  • Omics approaches have provided insights into cGVHD pathophysiology.
  • Drug targetable biomarkers with therapeutic potential have been identified.

Conclusions:

  • Biomarker discovery using omics is essential for advancing cGVHD diagnostics, prognostics, and therapeutics.
  • Further research is needed to overcome challenges in biomarker application for patient management.
  • Targetable biomarkers hold promise for novel drug development in cGVHD.
Abstract

Keywords:
Chronic graft-versus-host disease (cGVHD)allogeneic hematopoietic stem cell transplantation (allo-HSCT)biomarkersomicstherapy

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