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Updated: Feb 12, 2026

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Published on: June 28, 2024
Peripheral Precocious Puberty Caused by Human Chorionic Gonadotropin Producing Pineal Gland Tumor
S K Hammadur Rahaman1, Deepak Khandelwal2, Rajesh Khadgawat2
1Department of Endocrinology, AIIMS, New Delhi, India. Correspondence to: Dr SK Hammadur Rahaman, Department of Endocrinology and Metabolism, AIIMS, New Delhi 110 029, India. skhammadbhu@gmail.com.
Background:
Pineal gland lesions usually present with central precocious puberty.
Case Characteristics:
A 3½-yr-old boy presented with precocious puberty. Clinically and biochemically, it was gonadotropin releasing hormone (GnRH) independent. Serum and CSF beta-hCG levels were increased. Thin section magnetic resonance imaging of brain revealed a pineal gland tumor.
Outcome:
He received chemotherapy followed by radiotherapy and responded well.
Message:
CSF beta-hCG should be measured in all cases of peripheral precocity, and if CSF beta-hCG is elevated, thin section magnetic resonance imaging of brain should be considered.
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