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Updated: Feb 12, 2026

A Step by Step Protocol for Subretinal Surgery in Rabbits
Published on: September 13, 2016
Propofol: a safe anaesthetic drug in experimental cardiac surgery in rabbits
Ackground:
Experimental surgery needs a pharmacological approach that can interfere with cardiac function.
Case Report:
In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent.
Results:
In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell injection.
Discussion:
The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic drugs, avoiding serious complications. We hypothesize that the functional cardio-respiratory depressor of different anaesthesiological drugs can be reversed by the contemporary administration of with adrenergic agents.
Key Words:
Arrhythmias, Cardiac ischemia, Cardiovascular toxicity, Propofol.
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