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Updated: Feb 12, 2026

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
Endothelial Dysfunction is Related to Glycemic Variability and Quality and Duration of Sleep in Adults With Type 1
Sarah S Farabi1, Laurie Quinn, Shane Phillips
1Sarah S. Farabi, PhD Division of Endocrinology, Metabolism and Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora. Laurie Quinn, PhD Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago. Shane Phillips, PhD Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago. Dan Mihailescu, MD College of Medicine, Endocrinology, Diabetes & Metabolism, University of Illinois at Chicago. Chang Park, PhD Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago. Mohammed Ali, MD, PhD Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago. Pamela Martyn-Nemeth, PhD Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago.
Background:
Elevated cardiovascular disease risk in people with type 1 diabetes (T1DM) is incompletely understood. Glycemic control, glycemic variability, and sleep quality and duration may relate to cardiovascular disease risk in this population via endothelial dysfunction.
Objective:
The aim of this study was to examine relationships among glycemic control, glycemic variability, sleep quality and duration, and endothelial function in adults with T1DM.
Methods:
Endothelial function was measured using flow-mediated dilation. Glycemic control and glycemic variability were measured using A1C and a continuous glucose monitor, respectively; sleep quality and duration were measured with the Pittsburgh Sleep Quality Index.
Results:
Twenty subjects were recruited. Reduced flow-mediated dilation and higher glucose levels were associated with poorer sleep quality (r = -0.51, P = .01; r = 0.52, P = .03). Subjects with shorter sleep duration had greater glycemic variability.
Conclusions:
Endothelial dysfunction (a precursor to cardiovascular disease) relates to glycemic control, glycemic variability, and sleep quality in T1DM.
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