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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Pleura of the Lungs01:13

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Gross Anatomy of the Lungs01:17

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Orthotopic Left Lung Transplantation in Rats
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Single vs. bilateral lung transplantation: when and why.

Shambhu Aryal1, Steven D Nathan

  • 1Inova Lung Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia, USA.

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Bilateral lung transplantation is often favored, but evidence for its superiority over single lung transplantation is limited. Individualized decisions are necessary due to a lack of high-quality data and organ shortages.

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Area of Science:

  • Pulmonary Medicine
  • Transplant Surgery

Background:

  • Lung transplantation is a critical treatment for end-stage lung diseases.
  • Despite increased procedures, many patients die awaiting organs.
  • The optimal surgical approach for non-septic lung conditions is debated.

Purpose of the Study:

  • To review the current evidence comparing single vs. bilateral lung transplantation.
  • To assess the optimal procedure for lung transplantation in non-septic conditions.

Main Methods:

  • Review of recent studies and available evidence on lung transplantation outcomes.
  • Analysis of comparative data for single versus bilateral lung transplantation.

Main Results:

  • Some studies suggest bilateral lung transplantation offers better long-term survival in pulmonary fibrosis and COPD.
  • However, the evidence supporting bilateral superiority is of low quality, lacking prospective studies.
  • Other studies show no significant outcome differences between single and bilateral procedures.

Conclusions:

  • High-quality evidence is insufficient to make definitive recommendations for lung transplant type.
  • Individual patient factors must guide the decision-making process.
  • Single lung transplantation should remain a viable option due to organ scarcity and waitlist numbers.